Plasma Proteomics/PTMs

Plasma Proteomics/PTMs

While plasma-derived protein biomarkers can provide earlier and better diagnosis for more effective treatments, very few protein biomarkers identified using proteomics have been introduced in the clinical practice. This is primarily due to immense complexities associated with plasma/serum analysis.

Why choose Tymora Analytical plasma proteomics/PTMs?

  • Our recently published manuscript in PNAS demonstrates for the first time the feasibility to identify thousands of phosphoproteins in plasma extracellular vesicles (EVs).
  • On average, using 1mL of plasma as the starting material, we can routinely identify more than 3,000 unique phosphopeptides, representing >1,200 unique phosphoproteins.
  • The identification numbers are significantly better than anything previously reported (highest previously reported number – 82 plasma EV phosphoproteins).
  • The analysis is based on comprehensive profiling of EVs secreted into blood by all cells, with diseased cells/tumors producing unique EVs with specialized cargo.
  • Our approach is the first and only method to successfully demonstrate the feasibility of developing plasma-derived EV phosphoproteins for disease profiling.

We now offer a unique and first-of-its-kind ability to analyze low abundant proteins, phosphoproteins, glycoproteins, and others directly from plasma EVs.

Our LC-MS/MS analysis-based services include:

  • Plasma EV Proteomics
  • Plasma EV Phosphoproteomics
  • Plasma EV Glycoproteomics
  • Other Plasma EV PTMs

We can also provide label-free quantitation, dimethyl labeling, and TMT-based quantitation. Most samples are analyzed within two to three weeks from receipt.

Contact us for more information.

Contact Tymora Analytical for more information about our plasma proteomics/PTMs services, to create a custom work plan based on your needs, and to get a quote. Business partnership opportunities are also available.
Contact us

Contact us for more information.

Contact Tymora Analytical for more information about our plasma proteomics/PTMs services, to create a custom work plan based on your needs, and to get a quote. Business partnership opportunities are also available.
Contact us