Plasma Proteomics/PTMs

Identify more EV (exosome) proteins/phosphoproteins with our plasma proteomics/PTMs analysis.

While plasma-derived protein biomarkers can provide earlier disease discovery for more effective treatments, plasma analysis has been incredibly complex. But, it shouldn’t have to be that way, especially when lives are on the line.

Tymora Analytical has developed a plasma EV (exosome) proteomics/PTMs technology to more effectively research and understand diseases. We’d love to share this method with you!

We can typically identify >1,000 unique proteins from just 10uL plasma, or 600-1,000 unique phosphoproteins from just 0.5mL plasma.

Why choose Tymora Analytical plasma EV proteomics/PTMs analysis?

  • In 2017, we published a manuscript in PNAS (Proceedings of the National Academy of Sciences) that shows, for the first time, the possibility of identifying thousands of phosphoproteins in plasma extracellular vesicles (EVs).
  • Our approach is the first and only method that successfully demonstrates the possibility of developing plasma-derived EV phosphoproteins for disease profiling, and we’re sharing our technology with other researchers.
  • With just 1mL of plasma, you can routinely identify more than 3,000 unique phosphopeptides, representing more than 1,200 unique phosphoproteins.
  • The identification numbers are significantly better than anything previously reported (the previous best ID result was 82 plasma EV phosphoproteins).
  • We’ve based our analysis on comprehensive profiling of EVs secreted into blood by all cells, with diseased cells and tumors producing unique EVs with specialized cargo.
  • With our EVtrap method, researchers like you can profile diseases more accurately—which leads to better treatments.

We’re excited to offer a unique, first-of-its kind ability to analyze proteins, phosphoproteins and other signaling molecules directly from plasma by EVtrap (Extracellular Vesicles Total Recovery and Purification).

Our plasma EVtrap and LC-MS/MS analysis-based services include:

  • Plasma EV Proteomics
  • Plasma EV Phosphoproteomics
  • Plasma EV Glycoproteomics
  • Other Plasma EV PTMs – contact us for more information.

What other plasma-based services does Tymora offer?

You can efficiently analyze plasma’s low abundant proteins, phosphoproteins, and glycoproteins when you partner with us. We can also help with label-free quantitation.

With Tymora, you can analyze most plasma samples within two to three weeks from receipt. This lets you profile diseases accurately and in a timely manner.

Want to learn more about our plasma proteomics/PTMs?

Contact us

Want to learn more about our plasma proteomics/PTMs?

Contact us