Saliva Proteomics/PTMs

Identify more biomarkers with our saliva EV (exosome) proteomics/PTMs analysis.

Saliva-derived protein biomarkers can help researchers understand diseases more thoroughly. Analyzing saliva in the clinical field has been complex in the past, but it doesn’t have to be that way.

Tymora Analytical has developed a saliva EV (exosome) proteomics/PTMs analysis method to more effectively identify biomarkers. We’d love to share this technology with you!

We can typically identify >1,000 unique proteins from just 20uL saliva, or 500-1,000 unique phosphoproteins from just 1mL saliva.

 

Why choose Tymora Analytical saliva EV proteomics/PTMs analysis?

 

  • In 2017, we published a manuscript in PNAS (Proceedings of the National Academy of Sciences) that shows, for the first time, the possibility of identifying thousands of phosphoproteins in extracellular vesicles (EVs) from biofluids.
  • We now have the ability to identify hundreds of phosphoproteins from saliva samples.
  • Our approach is the first and only method that successfully demonstrates the possibility of developing saliva-derived EV phosphoproteins for disease profiling, and we’re sharing our technology with other researchers.
  • With just 1mL of saliva, as the starting material, you can routinely identify more than 1,700 unique phosphopeptides, representing more than 700 unique phosphoproteins.
  • The identification numbers are significantly better than anything previously reported (the previous ID result was 65 saliva phosphoproteins).
  • We’ve based our analysis on comprehensive profiling of EVs secreted into saliva by all cells, with diseased cells and tumors producing unique EVs with specialized cargo
  • Our EVtrap method allows you to extract more than 95% of all saliva EVs with very low contamination levels.
  • With our EVtrap method, researchers like you can profile diseases more accurately—which leads to better treatments.

We’re excited to offer a unique, first-of-its kind ability to analyze proteins, phosphoproteins and other signaling molecules directly from saliva by EVtrap (Extracellular Vesicles Total Recovery and Purification).

Our saliva EVtrap and LC-MS/MS analysis-based services include:

  • Saliva EV Proteomics
  • Saliva EV Phosphoproteomics
  • Saliva EV Glycoproteomics
  • Other Saliva EV PTMs – contact us for more information.

What other saliva-based services does Tymora offer?

You can efficiently analyze saliva’s low abundant proteins, phosphoproteins, and glycoproteins when you partner with us. We can also help with label-free quantitation.

With Tymora, you can analyze most saliva samples within two to three weeks from receipt. This lets you profile diseases accurately and in a timely manner.

Want to learn more about our saliva proteomics/PTMs?


Contact us

Want to learn more about our saliva proteomics/PTMs?


Contact us