Urine Proteomics/PTMs

Urine Proteomics/PTMs

Urine analysis offers certain noteworthy advantages compared to blood, including truly non-invasive sampling, opportunity for more frequent collection, and larger obtainable volumes. However, analysis of clinically-relevant urine proteins or protein modifications has been incredibly challenging.

Why choose Tymora Analytical urine proteomics/PTMs?

  • Our recently published manuscript in PNAS demonstrates for the first time the feasibility to identify thousands of phosphoproteins in plasma extracellular vesicles (EVs).
  • We have now also developed the ability to identify hundreds of phosphoproteins from urine samples (manuscript in preparation).
  • On average, using 10mL of urine as the starting material, we can routinely identify more than 1,700 unique phosphopeptides, representing > 800 unique phosphoproteins.  
  • The identification numbers are significantly better than anything previously reported (highest previously reported number – 14 urine phosphoproteins).
  • The analysis is based on selective profiling of EVs secreted into urine by all cells, with diseased cells/tumors producing unique EVs with specialized cargo.
  • Our approach to date is the first and only method to successfully demonstrate the feasibility of developing urine-derived EV phosphoproteins for disease profiling.

We now offer a unique and first-of-its-kind ability to analyze low-abundant proteins, phosphoproteins, glycoproteins, and others directly from urine.

Our LC-MS/MS analysis-based services include:

  • Urine EV Proteomics
  • Urine EV Phosphoproteomics
  • Urine EV Glycoproteomics
  • Other Urine EV PTMs

We can also provide label-free quantitation, dimethyl labeling, and TMT-based quantitation.

Most samples are analyzed within two to three weeks from receipt.

Contact us for more information.

Contact Tymora Analytical for more information about our urine proteomics/PTM services, to create a custom work plan based on your needs, and to get a quote. Business partnership opportunities are also available.
Contact us

Contact us for more information.

Contact Tymora Analytical for more information about our urine proteomics/PTM services, to create a custom work plan based on your needs, and to get a quote. Business partnership opportunities are also available.
Contact us