Find non-invasive biomarkers more easily with our urine EV (Exosome) proteomics/PTMs analysis.
Urine analysis offers several advantages over plasma analysis, including truly non-invasive sampling, the opportunity for more frequent collection, and larger obtainable volumes.
Analyzing clinically relevant urine proteins or protein modifications has been challenging, but it doesn’t have to be that way. We’d love to collaborate with you and share our urine EV (exosome) proteomics/PTMs technology!
We can typically identify >1,200 unique proteins from just 0.2mL urine, or 800-1,000 unique phosphoproteins from just 10mL urine.
Why choose Tymora Analytical urine EV proteomics/PTMs analysis?
- We now have the ability to identify hundreds of phosphoproteins from urine samples as well (see our 2018 manuscript in JPR).
- Our approach is the optimal method for successfully demonstrating the possibility of developing urine-derived EV phosphoproteins for disease profiling, and we’re sharing our technology with other researchers.
- With just 10mL of urine, you can routinely identify more than 3,200 unique phosphopeptides, representing more than 1,200 unique phosphoproteins.
- The identification numbers are significantly better than anything previously reported (the previous best ID result was 14 urine EV phosphoproteins).
- We’ve based our analysis on comprehensive profiling of EVs secreted into urine by all cells, with diseased cells and tumors producing unique EVs with specialized cargo.
- Our EVtrap method allows you to extract more than 95% of all urine EVs with very low contamination levels.
- With our EVtrap method, researchers like you can profile diseases more accurately—which leads to better treatments.
We’re excited to offer a unique, first-of-its kind ability to analyze proteins, phosphoproteins and other signaling molecules directly from urine by EVtrap (Extracellular Vesicles Total Recovery and Purification).
Our urine EVtrap and LC-MS/MS analysis-based services include:
- Urine EV Proteomics
- Urine EV Phosphoproteomics
- Urine EV Glycoproteomics
- Other Urine EV PTMs – contact us for more information.
What other urine-based services does Tymora offer?
You can efficiently analyze urine’s low abundant proteins, phosphoproteins, and glycoproteins when you partner with us. We can also help with label-free quantitation.
With Tymora, you can analyze most urine samples within two to three weeks from receipt. This lets you profile diseases accurately and in a timely manner.